THE EFFECT OF ANTHRAQUINONE DERIVATIVES ON SERUM GAMMA-GLUTAMYL TRANSFERASE ACTIVITY IN HIGH-FAT DIET-INDUCED OBESITY IN WISTAR RATS

ABSTRACT

This study investigates the effects of anthraquinone derivatives on serum gamma-glutamyl transferase (GGT) activity in Wistar rats with high-fat diet-induced obesity. Obesity, a major risk factor for metabolic disorders, is commonly linked to elevated serum enzyme activities, particularly GGT, which is associated with oxidative stress and hepatic dysfunction. Anthraquinone derivatives, such as emodin and rhein, are known for their pharmacological properties, including anti-inflammatory and lipid-regulating effects, and are proposed as potential modulators of metabolic processes affected by obesity. The study employed 80 male Wistar rats divided into control and experimental groups, with obesity induced by a high-fat diet over an eight-week period. Subsequently, anthraquinone derivatives were administered to evaluate their impact on serum GGT levels, body weight, and other biochemical markers. Serum GGT activity was measured using spectrophotometric analysis, and body weight changes were tracked over time to assess the compounds' metabolic effects. The findings reveal that anthraquinone derivatives significantly reduced serum GGT activity and improved lipid profiles, suggesting their potential role in managing oxidative stress and hepatic damage associated with obesity. Furthermore, weight reduction observed in treated groups aligns with the anti-adipogenic effects documented in prior studies on anthraquinones. This research contributes to understanding the biochemical mechanisms underlying the anti-obesity potential of anthraquinone derivatives. These findings provide a foundation for future clinical trials to further assess the applicability of anthraquinone derivatives as adjunctive therapies in obesity management. However, the study highlights the need for further exploration into the long-term safety and efficacy of these compounds in both animal and human models.